Skin-lightening agents: New chemical and plant extracts -ongoing search for the holy grail!

Are plant DNA barcodes a search for the Holy Grail?

In a recent study, Kress et al. compared two plant genomes to seek out plant DNA barcodes. Two promising markers balanced the variability that is needed to distinguish species with conserved primer regions that enable universal amplification. Although this study is the most rigorous effort to date, problems from earlier barcoding efforts, such as the use of non-evolutionary species concepts and...

CH2D(+), the search for the holy grail.

CH2D+, the singly deuterated counterpart of CH3(+), offers an alternative way to mediate formation of deuterated species at temperatures of several tens of Kelvin, as compared to the release of deuterated species from grains. We report a longstanding observational search for this molecular ion, whose rotational spectroscopy is not yet completely secure. We summarize the main spectroscopic prope...

Prevention of chronic postsurgical pain: the ongoing search for the holy grail of anesthesiology.

241 February 2013 W e all know them. Perhaps it is the “funny uncle” you see only at family reunions, or the high-school friend who was sent away to live with relatives in a “better environment.” every profession has their share, those things that all too often get “tucked away into some closet,” or “swept under a rug.” In social work services, they might come under the guise of “domestic viole...

Quantifying diastolic function in hypertrophic cardiomyopathy: the ongoing search for the holy grail.

Hypertrophic cardiomyopathy (HCM) is a primary autosomal-dominant disorder of the myocardium caused by mutations in sarcomeric contractile proteins. Histopathologically, it is associated with myocardial hypertrophy, fiber disarray, increased loose connective tissue, and fibrosis, which are all thought to interfere with myocardial force generation and relaxation.1–3 There is tremendous heterogen...

In search of the Holy Grail.